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T-Cell Leukemia Lymphoma Foundation

To provide education and support to patients and to encourage research into these rare cancers

  • Provides disease, treatment and clinical trial information for the T-cell leukemias and lymphomas
  • Organizes free educational forums
  • Offers physician referrals, e-newsletter and links to helpful resources
  • Supports scientific research on the T-cell leukemias and lymphomas.

Patients, caregivers, healthcare professionals, researchers

Website or 206-661-2253 http://www.tcllfoundation.org/

Abrale (Brazilian Lymphoma and Leukemia Society)

To support cures and improve the quality of life for people living with blood cancer in Brazil.

  • Serves Brazil and Latin America
  • Provides disease, treatment and clinical trial information as well as materials about blood cancers
  • Offers psychological, legal, nutritional support and more
  • Advocates for patient access to treatment

Patients, caregivers, health professionals

Website or +55 11 3149-5190 http://www.abrale.org.br/
International Resources
International Resources

Chronic Myeloid Leukemia 3D Model

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This model contains the following chapters. Click the "Interact in 3D" button to begin.

  • Healthy Bone Marrow
  • Normal Blood Cell Production
  • Proliferation of Cells and the Crowding Out of Normal Cells
  • Signs and Symptoms

Chronic Lymphocytic Leukemia 3D Model

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This model contains the following chapters. Click the "Interact in 3D" button to begin.

  • Healthy Bone Marrow
  • Normal Blood Cell Production
  • Proliferation of Cells and the Crowding Out of Normal Cells
  • Signs and Symptoms

Acute Myeloid Leukemia 3D Model

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This model contains the following chapters. Click the "Interact in 3D" button to begin.

  • Healthy Bone Marrow
  • Normal Blood Cell Production
  • Proliferation of Cells and the Crowding Out of Normal Cells
  • Signs and Symptoms

Acute Leukemia Advocates Network (ALAN)

To change the outcomes of acute leukemia patients by strengthening patient advocacy.

  • ALAN is an independent global network of patient organizations which aims to increase awareness about the acute leukemias, share best practices, advocate for better access and treatment, and improve education for healthcare professionals.

Healthcare professionals, patient advocates

Website http://acuteleuk.org/
International Resources
Canadian Resources International Resources U.S. Resources

Role of HLX in leukemia induction and maintenance

We and others have shown how HLX overexpression keeps blood cells more immature by blocking their differentiation and promoting their proliferation, a characteristic which is inherent to AML. However, whether there is a causative role of HLX in the induction of AML is still unclear. Hence, the aim of my study is to better understand, using genetically engineered mice models, retroviral models, and human AML patient samples, how HLX drives AML at molecular level. This study will uncover potential therapeutic strategies for AML treatment in future.

Early diagnosis and treatment of pre-leukemia

In the current study we propose, based on our preliminary results, that we can reliably identify pre-AML cases out of the many individuals with age related clonal hematopoiesis (ARCH) based on clinical parameters thereby limiting the population that needs to undergo molecular testing. We have also developed a predictive model that can identify pre-AML cases years before diagnosis. We now propose to utilize this knowledge to treat high-risk individuals with ARCH, at a time point before they have developed disease, by targeting the driving alterations most associated with AML development.

Targeting cathepsin G in acute myeloid leukemia

We developed a chimeric antigen receptor (CAR) targeting an epitope of the myeloid associated antigen cathepsin G that is processed and presented in the contest of the MHC complex in myeloid leukemic cells. T cells expressing the cathepsin G specific CAR (CG1.CAR) recognize HLA-A2+ myeloid target cells expressing cathepsin G. We intend to study efficacy and safety of CG1.CAR-T cells in preclinical models in preparation of a phase I clinical study in patients with relapsed/refractory AML.

Children’s Leukemia Research Association (CLRA)

To support research efforts towards finding the causes and cure for leukemia.

  • Patient Aid Program offers limited funds (up to $3,000 per year) to assist with certain treatments, services and prescriptions; funds are available on a first-come, first-serve basis
  • CLRA funds grants to doctors conducting promising research about leukemia.

Children and adults with blood cancer in the U.S., healthcare professionals and researchers

516-222-1944 http://www.childrensleukemia.org/
International Resources
Canadian Resources U.S. Resources

LLS & BURLINGTON: CREATING A BRIGHTER TOMORROW FOR BLOOD CANCER PATIENTS

Each September, during Blood Cancer Awareness Month, Burlington and The Leukemia & Lymphoma Society (LLS) team up to create awareness for the urgent need to fund research to advance cancer cures for the nearly 1.3 million people in the U.S. are living with, or are in remission from a blood cancer.