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KT1, a novel NK trispecific antibody for the treatment of AML and MDS
New treatments for AML and MDS are urgently needed. We have developed and performed preliminary testing of a novel, patent-protected, trispecific NK cell engager named KT1 which targets AML blasts and leukemia stem cells (LSCs) expressing CD33 and CD123 for elimination by effector cells that express CD16a/b.
Alesia
In November 2021, I experienced my first panic attack while at work. I went to the urgent care clinic, and they tested me and said I was good and might be experiencing anxiety. At that time, being a teacher in my school was hard and overwhelming, and I started taking anxiety medication. Later on in the school year, I continued to experience COVID-like symptoms but was always negative. I did eventually get COVID, but I was still healthy on paper. While all of this was going on, I was also encountering fatigue that I couldn't explain and blamed it on my job.
Ariel
I was diagnosed with acute promyelocytic leukemia (APL) on January 24, 2019. I hadn’t been feeling well for a while. I was having very odd symptoms. For example, I was having joint pains, I kept hearing this whooshing noise, my gums were bleeding, and the biggest symptom was I would get out of breath so easily. Walking up the steps of my apartment building felt like running a marathon. I went to an urgent care clinic and described these symptoms, and the doctor gave me an antibiotic and sent me home. I’ll never forget his face before he discharged me. I could see he was unsure.
Andre
In July 1993 I was blessed with my son, Andre Christopher Jordan. He's my heart, pride and joy. Throughout his young life, Andre's has humbled me with his love, kindness, strength, loyalty and faith. Two years ago, he and his fiancé, Ana were blessed with their son. He was overjoyed with being a new father and had marriage plans in the works. He had just received a promotion at work that he had worked hard for and all was well. Then suddenly, Andre's life suddenly took a tragic turn.
Amanda
"He was selfless, unbelievably selfless," said Amanda about her father, Andrew. "He did everything for everybody. He worried enough for our family plus more. And never showed it. He worked extremely hard to provide us with everything we could possibly need."
Aaron
Aaron was taken to urgent care after he developed a rash that didn't seem right. The next day, he was admitted into The Children's Hospital, and 36 hours later he was diagnosed with acute lymphoblastic leukemia (ALL).
Watch and Wait
Watch and wait (also called active surveillance) involves closely monitoring a patient's condition without giving any treatment until symptoms appear or change. Some people can manage their blood cancer — depending on the disease — with their doctors for years using a watch-and-wait approach. It is usually recommended for patients in early stages of indolent (slow-growing) or chronic forms of blood cancers.
Amanda
As a popular entertainment anchor on the “Good Day LA” morning show in Los Angeles, Amanda Salas has always kept busy. But after she was diagnosed with non-Hodgkin lymphoma in June 2019, she has had to refocus all her energy and time on fighting for her life.
Kyle
In April 2019, Kyle, a 17-year-old football star at Glenn Hills High School in Hephzibah, Georgia, noticed a large lump on his throat while taking a shower. After a trip to the hospital and several tests, he was diagnosed with Hodgkin lymphoma and began intense treatment right away.
Yesenia
My name is Yesenia and this is my story. I began my first semester of university in fall 2017. While I was away for college I started experiencing some symptoms. It started off with nausea, after the first couple weeks of fall semester I would experience this sensation that left me bed ridden. This led me to go back to my family home so I could be better taken care of. I knew at that point that something wasn't right, so I took a trip to Urgent Care where I was told I was Anemic, but with a better diet I would go back to normal.
Jaimie Potvin
Finding cures for cancer is especially close to my heart. In 2011, my brother, Cory was diagnosed with large B-cell lymphoma. Our dad was already a two-time survivor of non-Hodgkin lymphoma, so we truly believed he would survive blood cancer too. When his treatment showed no signs of improvement, it was devastating. Cory died six years ago and I still miss him so much every single day.
Andrea
In October 2015, my family had just moved to Texas for a new start. I had a new career, and two young boys ― a 2-year-old and a 7-year-old.
I wasn’t feeling well and went to urgent care one day where we discovered my white blood cell count was 113. They sent me straight to the ER where I was all alone because we had no one here yet and couldn’t bring the kids to the hospital. Three days later, I was diagnosed with chronic myeloid leukemia (CML).
Kimberlee
On December 29, 2023, my life took an unexpected turn. My family and I were traveling to California for the holidays when, during takeoff back to Georgia, I felt a sudden pop in my chest as the cabin pressure changed. I was immediately struck by intense pain, unable to move or catch my breath. Determined to hold on until we landed, I braced myself through the agony.
Maria
By the end of November 2008, I started feeling an overwhelming fatigue. I developed a fever and my physician sent me urgently to the emergency room. There I was found to be depleted of blood and needed a transfusion. It seemed so unreal.
After a couple of days and a bone marrow biopsy, I was diagnosed with acute myeloid leukemia (AML). I learned that if I had not sought help in the ER, I could had died.
Samantha
In February 2023, I was on top of the world. I turned 27 years old, I was training for a new position at my dream company, I spent an amazing weekend in Nashville with girlfriends, and had just touched down from Mexico after spending a fantastic weekend with one of my best friends. Everything felt right ― for the most part. While this month was filled with love, laughter, and good times, it was also filled with night sweats, stomach pains, and overall feelings of illness.
Avi
My journey began a few months into 2020. I was making plans to celebrate my birthday by going to some amusement parks I hadn't been to in many years. Unfortunately, that's when the pandemic hit, and going to the parks was no longer an option. A few months later, I started to get sick. Fever, night sweats, little to no appetite, weight loss. We didn't know if it was COVID-19 or not. I went to urgent care, and they didn't help (sent me home with Tylenol), and I was still not feeling it. I went to get bloodwork as something was off and I was starting to show signs of jaundice.
Cristina
My story begins in October of 2018. I had recently graduated from college, moved away from home for the first time, settled into my own apartment, and started a full-time job. I felt like I was on the verge of greatness with all of these new and exciting beginnings in my life. I didn't know that I was about to have another massive beginning... the beginning of my battle with Hodgkin's Lymphoma. I was sitting at a cancer fundraiser dinner, anxiously twirling the spaghetti on my plate. I had a gut wrenching feeling in my chest that something was wrong.
William
Hi, my name is William Yank and I am a 23-year-old, three-time leukemia survivor from Indiana. My story begins at the end of my junior year of college. I had just secured an internship in Washington D.C and was excited to finally spend a summer on my own. The summer started off pretty rough. I struggled to find affordable housing in D.C, I had no idea how the transportation system worked, and food was twice as expensive as compared to Indiana. Not to mention, I was only 20-years-old having fun was next to impossible.
Disease Complications
Myeloma and treatment of myeloma can lead to mild to serious health complications and side effects. Some of these symptoms can be managed with ongoing supportive (palliative) care. Others may be medical emergencies requiring immediate attention. Always tell your healthcare team if you experience new or worsening symptoms.
PainPain related to myeloma or myeloma treatment can include
Tricia
My name is Tricia, and I am a two-time cancer survivor. In 2017, at the age of 27, I got a positive pregnancy test. We were elated! We already had a three-year-old daughter and couldn't wait to expand our family. I made an appointment with my OB-GYN to confirm the pregnancy and get a due date when she found a lump on my thyroid. I was constantly assured it would be nothing. Unfortunately, after a biopsy, it was confirmed to be thyroid cancer. I underwent surgery to remove half of my thyroid that had the tumor. It was very scary going under the knife since I was pregnant at the time.
Tawilhua
My name is Tee, and I am a survivor of multiple myeloma (MM), a rare blood cancer. Before my diagnosis, I was an active principal at the school where I worked, was involved in my community, and lived a life of purpose. And then I was diagnosed with the “Big C.”
Today, I still have a purpose-filled life, it simply looks different than before. Telling my cancer story is a part of living a fulfilled life after a cancer diagnosis. So here is Tee’s story.
Aryan
Hello, my name is Aryan. I am 13 years old. I was almost five years old when I first got diagnosed with cancer. It started as a normal summer like always, and we were planning to go somewhere. My dad was always traveling because of work, so it was just me and my mom. I would mostly spend time at my grandparents’ house because I could play games with them. One day my dad saw a bump on the back of my head, and our pediatrician told us that it was a lymph node. My pediatric doctor told my parents that it's normal, part of recovery from a fever or cough and to monitor it.
Jelien
Jelien started showing signs in early July of 2018. She had bruises and cuts that were taking too long to heal. In November, she kept spiking fevers with no other symptoms, and the doctor suggested giving her Motrin and switching to Tylenol. In December, during her well visit, Jelien’s bloodwork came back with slightly low counts, but her hemoglobin was too low. She was admitted to the hospital for a day for observation, and her counts were recovering. She had a follow-up and was cleared.