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“Stages” of Leukemia: Understanding Classification and Progression
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Leukemia vs. lymphoma: What you need to know
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Ask the Doctor Part 2: Five Questions about Lymphoma
Lymphoma survivor, Jessica Melore talks to Dr. Nichols about the Latest in Lymphoma Research and Treatment
Predisposing factors to leukemia
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Midostaurin
Rydapt is FDA approved for the treatment of adult patients with:
- Newly diagnosed acute myeloid leukemia (AML) that is FLT3 mutation positive as detected by an FDA-approved test, in combination with standard cytarabine and daunorubicin induction and cytarabine consolidation.
Limitations of Use:
RYDAPT is not indicated as a single-agent induction therapy for the treatment of patients with AML. - Aggressive systemic mastocytosis (ASM), systemic mastocytosis with associated hematological neoplasm (SM-AHN), or mast cell leukemia (MCL).
Enasidenib
Enasidenib (Idhifa®) is FDA approved for the treatment of adult patients with relapsed or refractory acute myeloid leukemia (AML) with an isocitrate dehydrogenase-2 (IDH2) mutation. The drug is approved for use with a companion diagnostic, the RealTime IDH2 Assay, which is used to detect specific mutations in the IDH2 gene in patients with AML.
Signs and Symptoms
Signs and symptoms vary from patient to patient and depend on the type of CMML. Click here to learn more about subtypes of CMML.
Those with a myelodysplastic subtype (MD-CMML) tend to present with low blood cell counts. Signs and symptoms may include:
Signs and Symptoms
Signs and symptoms are changes in the body that may indicate disease. A sign is a change that the doctor sees during an examination or on a laboratory test result. A symptom is a change that a patient can see and/or feel. A person who has signs or symptoms that suggest the possibility of leukemia is usually referred to a specialist. This is a hematologist-oncologist. A hematologist-oncologist is a doctor who has special training in diagnosing and treating blood cancers such as leukemia, lymphoma and myeloma.
Signs and Symptoms
Essential thrombocythemia (ET) is often detected during a routine blood test before an individual has any symptoms.
The signs and symptoms of ET are linked to high platelet counts that cause the development of a thrombus (blood clot). The symptoms include:
Signs and Symptoms
In the early stages of myeloma, some patients have no signs or symptoms of the disease. It is sometimes detected before symptoms appear, when results of laboratory tests done as part of a routine medical examination show abnormalities in the blood and/or urine. When symptoms are present, the most common ones are bone pain and fatigue.
Signs of MyelomaDoctors sometimes refer to the acronym, CRAB, to describe signs of myeloma. The letters stand for
Signs and Symptoms
A person who has signs or symptoms that suggest the possibility of non-Hodgkin lymphoma (NHL) is usually referred to a blood cancer specialist called a hematologist-oncologist. The doctor will order additional tests and a tissue biopsy to make a diagnosis. The signs and symptoms of NHL are also associated with a number of other, less serious diseases.
The most common early sign of NHL is painless swelling of one or more lymph node(s).
Signs and Symptoms
People who have chronic myeloid leukemia (CML) may not have any symptoms at first. Often, patients learn they have CML after a routine physical exam or a blood test. CML signs and symptoms tend to develop gradually. Those with symptoms often report experiencing:
Signs and Symptoms
Signs and symptoms are changes in the body that may indicate the presence of disease. A sign is a change that the doctor sees during an exam or in a laboratory test result. A symptom is a change that a patient can see and/or feel.
It is common for a child with ALL to feel a loss of well-being because of the lack of normal, healthy blood cells.
Symptoms of a low red blood cell count (anemia) include:
Signs and Symptoms
The signs and symptoms of hairy cell leukemia aren't specific and are common to other, less serious illnesses. However, if you're troubled by any of the following symptoms, see your doctor:
Decitabine
Decitabine is FDA approved to treat adults with myelodysplastic syndromes (MDS) or chronic myelomonocytic leukemia.
Signs and Symptoms
The signs and symptoms of acute myeloid leukemia (AML) are common to other, less serious illnesses. However, if you're troubled by any of the following symptoms, see your doctor:
It is common for people with AML to feel a loss of well-being because of the underproduction of normal bone marrow cells.
Symptoms of a low red blood cell count (called “anemia”) include:
Signs and Symptoms
The most common symptom of Hodgkin lymphoma is one or more enlarged (swollen) lymph nodes. The enlarged lymph node may be in the neck, upper chest, armpit, abdomen or groin. The swollen lymph node is usually painless.
Other signs and symptoms of Hodgkin lymphoma may include
Rasburicase
Rasburicase is FDA approved for the initial management of plasma uric acid levels in patients with leukemia, lymphoma and solid tumors who are receiving certain types of anticancer therapy expected to result in elevated plasma uric acid.
Signs and Symptoms
MF usually develops slowly. MF often does not cause early symptoms and may be found during a routine blood test. When fibrosis develops in the bone marrow, the bone marrow is unable to produce enough normal blood cells. The lack of blood cells causes many of the signs and symptoms of MF. These include:
Signs and Symptoms
It is common for children with AML to feel a loss of well-being because of the underproduction of normal bone marrow cells.
Symptoms of a low red blood cell count (called “anemia”) include the following:
- Fatigue
- Weakness
- Shortness of breath during normal physical activities
- Lightheadedness, dizziness or faintness
- Headaches
- Pale complexion
Symptoms of a low white blood cell count (called “neutropenia”) include the following:
Signs and Symptoms
Some patients initially have no symptoms of MDS, and abnormal results from routine blood tests may be the earliest signs of the disease. For patients with symptoms, it is common not to feel well because of the lack of normal, healthy blood cells.
Anemia is a decrease in the number of healthy red blood cells. Red blood cells carry oxygen throughout the body. Anemia may cause symptoms such as:
Signs and Symptoms
Children who have juvenile myelomonocytic leukemia (JMML) may have the following signs and symptoms:
- Difficulty breathing and/or dry cough
- Enlarged lymph nodes
- Abdominal pain and loss of appetite caused by enlarged kidney, liver and/or spleen
- Bone and joint pain
- Fatigue and pale skin (from low level of red blood cells)
- Easy bruising and bleeding (from low level of platelets)
- Frequent infections (from low level of white blood cells)
Some children also have skin changes which can include
Lymphoma diagnosis, survival rate by age, prognosis, and treatment
Table of contents:
Ask the Doctor Part 3: Five Questions about Myeloma
Myeloma Survivor, Sharon Clark Talks to Dr. Nichols about the Latest in Myeloma Research and Treatment
The History of Leukemia
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