Kymera Therapeutics Presents Preclinical Data and Shares Profile of Clinical Candidate KT-253 at the AACR Annual Meeting 2022
Current TAP Partner
WATERTOWN, Mass., April 08, 2022 (GLOBE NEWSWIRE) -- Kymera Therapeutics, Inc. (NASDAQ: KYMR), a clinical-stage biopharmaceutical company advancing targeted protein degradation to deliver novel small molecule protein degrader medicines, today presented preclinical data from its 4th development program, a novel MDM2 degrader, at the American Association for Cancer Research (AACR) Annual Meeting 2022, taking place from April 8 - 13, 2022 in New Orleans, Louisiana.
KT-253 is a potent and selective degrader of MDM2 with potential to be a best-in-class p53 stabilizer. Degradation of MDM2 has blocks the feedback loop which up-regulates MDM2 production and in doing so more effectively drives tumor cells to rapid apoptosis. As wild-type p53 is present in more than 50% of tumors, KT-253 represents another program with broad franchise potential in liquid and solid tumors. Kymera is focused on indications with specific sensitivity to this mechanism of action, such as AML, lymphomas, uveal melanoma, and others through a focused biomarker strategy. Kymera expects to file an IND for KT-253 in 2022.
Presentation at AACR Annual Meeting:
- Title: KT-253, a highly potent and selective heterobifunctional MDM2 degrader for the treatment of wild-type p53 tumors with superior potency and differentiated biological activity compared to small molecule inhibitors (SMI)
- Abstract Number: 3934 / 8
- Session Time: 9:00 AM – 12:30 PM CDT, April 13, 2022
- Presenter: Yogesh Chutake, Principal Scientist, Oncology, Biology, Kymera Therapeutics