Kymera Therapeutics Presents Positive Preclinical Data on Selective STAT3 Degraders for Hematological and Solid Tumor Malignancies at 63rd American Society of Hematology (ASH) Annual Meeting

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Kymera

WATERTOWN, Mass., Dec. 13, 2021 (GLOBE NEWSWIRE) -- Kymera Therapeutics, Inc. (NASDAQ: KYMR), a biopharmaceutical company advancing targeted protein degradation to deliver novel, small molecule protein degrader therapeutics, today announced the company presented new preclinical data for its STAT3 degraders, including its first-in-class KT-333 STAT3 degrader, at the virtual 63rd American Society of Hematology (ASH) Annual Meeting taking place from December 11 – 14, 2021 in Atlanta, GA and virtually.

Kymera’s first presentation, “A First-in-Class STAT3 Degrader KT-333 in Development for Treatment of Hematologic Cancers” showcased how its clinical compound KT-333 induced growth arrest and cell death in multiple models of anaplastic large cell lymphoma (ALCL). This resulted in eradication of ALK+ ALCL tumor xenografts with weekly or every other week dosing associated with >90% STAT3 knockdown in tumors and modulation of STAT3-dependent signaling. In addition, KT-333 reduced mediators of immune suppression in an ex vivo, co-culture model of the tumor microenvironment in non-small cell lung cancer and led to tumor regressions in the mouse CT-26 colorectal cancer syngeneic tumor model when coupled with an anti-PD1 antibody, demonstrating the potential for this combination immunodulatory approach in solid tumors.

KT-333 Presentation Details:

  • Title: A First-in-Class STAT3 Degrader KT-333 in Development for Treatment of Hematologic Cancers
  • Poster Session: 802. Chemical Biology and Experimental Therapeutics: Poster 1
  • Abstract Number: 1865
  • Session Time: 5:30 p.m. – 7:30 p.m. ET on Saturday, Dec. 11, 2021
  • Location: Hall B5, Georgia World Congress Center, Atlanta, GA
  • Presenter: Phillip Liu, Executive Director, Oncology Biology, Kymera Therapeutics

The second presentation, “Selective STAT3 Degraders Dissect Peripheral T-Cell Lymphomas Vulnerabilities Empowering Personalized Regimens” highlights results from a research collaboration with Georgio Inghirami, MD, Weill Cornell Medical College. In primary patient-derived tumor xenograft (PDTX) models of anaplastic large cell lymphoma (ALCL), selective STAT3 degraders were shown to potently degrade STAT3 and modify STAT3-dependent signaling, leading to tumor growth inhibition and cell death in an ALK- ALCL model characterized by STAT3 activation via STAT3 and Jak1 mutations. STAT3 degraders were also shown to synergize with other targeted agents, such as venetoclax, in various peripheral T-cell lymphoma (PTCL) PDTX models.

KTX-105 and KTX-154 Presentation Details:

  • Title: Selective STAT3 Degraders Dissect Peripheral T-Cell Lymphomas Vulnerabilities Empowering Personalized Regimens
  • Oral Session: 605. Molecular Pharmacology and Drug Resistance: Lymphoid Neoplasms: Novel Targets and Therapeutics
  • Session Time: 6:15 p.m. – 7:45 p.m. ET on Monday, Dec. 13, 2021
  • Location: B302-B303, Georgia World Congress Center, Atlanta, GA
  • Presenter: Giorgio Inghirami, MD, Professor of Pathology and Laboratory Medicine, Weill Cornell Medicine

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