Immune-Onc Therapeutics Makes Two Presentations of IO-108, a Novel Clinical-Stage Myeloid Checkpoint Inhibitor Targeting LILRB2 (ILT4), at the AACR 2022 Annual Meeting

PALO ALTO, CA, April 8, 2022 / Business Wire / -- Immune-Onc Therapeutics, Inc. (“Immune-Onc”), a private, clinical-stage cancer immunotherapy company developing novel biotherapeutics targeting myeloid checkpoints, today announced two poster presentations on its clinical stage program IO-108, a novel myeloid checkpoint inhibitor targeting Leukocyte Immunoglobulin-Like Receptor B2 (LILRB2, also known as ILT4), at the American Association for Cancer Research (AACR) Annual Meeting in New Orleans, Louisiana.

Tumor-associated myeloid cells are immunosuppressive cells that contribute to impaired anti-tumor responses, and limit the efficacy of currently approved cancer immunotherapies, such as T cell checkpoint inhibitors. LILRB2 is a receptor expressed primarily by myeloid cells that has several ligands known to contribute to immune suppression in the tumor microenvironment (TME).  

Details of Immune-Onc’s AACR 2022 presentations are as follows:

Title: IO-108, A fully human therapeutic antibody blocking the myeloid checkpoint LILRB2/ILT4, promotes innate and adaptive anti-cancer immunity in preclinical studies
Abstract Number: 601
Presentation Time: April 10, 2022, 1:30 PM – 5:00 PM ET

Title: A first-in-human phase 1 trial of IO-108, an antagonist antibody targeting LILRB2 (ILT4), as monotherapy and in combination with pembrolizumab in adult patients with advanced relapsed or refractory solid tumors (NCT05054348)
Abstract Number: CT209
Presentation Time: April 12, 2022, 9:00 AM – 12:30 PM ET