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Affimed Announces Acceptance of Three Abstracts at the 2024 ASH Annual Meeting Including an Oral Presentation Underscoring Advancing Clinical Pipeline in Leukemia and Lymphoma

Affimed

MANNHEIM, Germany, Nov. 05, 2024 - Affimed N.V. (Nasdaq: AFMD) (“Affimed”, or the “Company”), a clinical-stage immuno-oncology company committed to giving patients back their innate ability to fight cancer, today announced three abstracts on two of its innate cell engagers (ICE®) are accepted for presentation at the 66th ASH Annual Meeting and Exposition taking place December 7-10, 2024, in San Diego, California. Updated clinical results from all 4 cohorts of the run-in phase from the LuminICE-203 study evaluating acimtamig (AFM13) in combination with AlloNK® (AB-101) for relapsed/ refractory Hodgkin Lymphoma will be shared in a poster session. An oral presentation will feature clinical results including promising efficacy and safety data from the AFM28 phase 1 dose escalation study in relapsed/refractory acute myeloid leukemia (AML) and poster with preclinical data will highlight the in vitro efficacy of AFM28 in combination with both patient-derived autologous NK cells and healthy volunteer-derived allogeneic NK cells against leukemic blasts.

Details for the oral presentation and poster sessions are as follows:

Abstract Title Date / Time / Presenter Session Name / Location
“Investigating the Novel Combination of the Innate Cell Engager (ICE®) Acimtamig with Off-the-Shelf Allogeneic Natural Killer Cells AlloNK® in Relapsed or Refractory Classical Hodgkin Lymphoma (R/R cHL): Initial Results of the Phase 2 Luminice-203 Study” December 8, 2024
6:00 PM – 8:00 PM PT

Joseph Maakaron, MD
Division of Hematology, Oncology and Transplantation, Department of Medicine, Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA
  • Session Name: 624. Hodgkin Lymphomas: Clinical and Epidemiological: Poster II
  • Location: San Diego Convention Center, Halls G-H
  • Publication Number: 3052
“Engaging Innate Immunity by AFM28, an Innate Cell Engager (ICE®) Targeting CD123-Positive Leukemic Cells in Patients with Relapsed/Refractory Acute Myeloid Leukemia: Safety and Efficacy Results of a First-in-Human Phase 1 Study” December 9, 2024
10:30 AM – 12:00 PM PT

Oral Presentation
Time: 11:45 AM PT

Pau Montesinos, MD, PhD
Hospital Universitari i Politècnic La Fe, Valencia, Spain
  • Session Name: 616. Acute Myeloid Leukemias: Investigational Drug and Cellular Therapies: New Treatment Approaches for AML
  • Room: Manchester Grand Hyatt San Diego, Grand Hall B
“The Bispecific Innate Cell Engager AFM28 Can Leverage AML Patient’s NK Cells in Addition to Allogeneic NK Cells, Enabling Elimination of CD123+ Leukemic Stem and Progenitor Cells in AML and MDS” December 9, 2024
6:00 PM – 8:00 PM PT

Nanni Schmitt, Dr. sc. hum.
Department of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
  • Session: 604. Molecular Pharmacology and Drug Resistance: Myeloid Neoplasms: Poster III
  • Location: San Diego Convention Center, Halls G-H

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