Avapritinib

Indications and Usage

Ayvakit® is indicated for the treatment of

• Advanced Systemic Mastocytosis (AdvSM) 
  • The treatment of adult patients with AdvSM. AdvSM includes patients with aggressive systemic mastocytosis (ASM), systemic mastocytosis with an associated hematological neoplasm (SMAHN), and mast cell leukemia (MCL). 
  • Limitations of Use: AYVAKIT is not recommended for the treatment of patients with AdvSM with platelet counts of less than 50 X 109 /L  
• Indolent Systemic Mastocytosis (ISM) 
  • The treatment of adult patients with ISM.
  • Limitations of Use: AYVAKIT is not recommended for the treatment of patients with ISM with platelet counts of less than 50 X 109 /L 

Side effects needing medical attention

• AdvSM: edema (swelling caused by too much fluid trapped in the body’s tissues), diarrhea, nausea, and fatigue/asthenia (abnormal physical weakness or lack of energy). 
• ISM: eye edema, dizziness, peripheral edema and flushing.