I began my scientific career in the Marchesi laboratories (Yale, 1982-1985) and then as an undergraduate under Don Wiley (Harvard, 1986-1988). I entered the Medical Scientist Training Program (1988-1995) at the University of California, San Francisco (UCSF), performing doctoral research with Harold Varmus, at UCSF and the NIH. I defended my thesis at UCSF and completed medical training at Northwestern (1996-1997). I was an Internal Medicine house officer and Hematology/Oncology fellow at Univ of Chicago (UofC, 1997-2003)then stayed on as a UofC faculty member as a physician-scientist, with both research and clinical responsibilities (2003-2023).

Effective April 1, 2023, I have joined the Feinberg School of Medicine at Northwestern University as the inaugural director of the Jeff and Marianne Silver Family Blood Cancer Institute of the Robert H. Lurie Comprehensive Cancer Center. I will also serve as Clinical Director of Cancer Genetics.

I derive synergy between bench research and the bedside to understand disease on a molecular level. This proposal seeks to understand how inherited DNA changes influence the development of bone marrow cancers, with the goal of developing interventions that would prevent cancers in at-risk individuals to make my job as an oncologist obsolete.