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Stem Cell Transplantation

Allogeneic Stem Cell Transplantation

An allogeneic stem cell transplantation is a treatment that uses stem cells from a healthy donor to restore a patient’s bone marrow that is damaged or diseased after receiving high doses of chemotherapy and/or radiation therapy. Allogeneic stem cell transplantation remains the only potential cure for MDS. 

Managing Side Effects

Work closely with your doctor and cancer care team to prepare yourself with information about what to expect and how to cope with side effects.  For some patients, side effects may last well after treatment is completed or may be permanent. For most patients, side effects are temporary and go away when the body adjusts to therapy or once treatment ends. On the other hand, some patients suffer symptoms that may require hospitalization until they subside.

Reactions to treatment vary from patient to patient. Reactions also vary depending on:

How to Find a Treatment Center

A number of resources are available to help you find a treatment center. Your primary care doctor may be able to provide a referral or you can use doctor and insurance referral services.

The National Cancer Institute (NCI) supports a national network of cancer centers. Each center must meet specific scientific, organizational and administrative criteria. See a list of NCI-approved cancer centers.

The following organizations can also help:

Survivorship

Survivorship Workbook

Use this Survivorship Workbook to collect all the important information you need throughout diagnosis, treatment, follow-up care and long-term management of a blood cancer.

Talking With Members of Your Oncology Team

Ask your oncology team about the fertility effects of your treatment. By having this information before treatment begins, you can consider the options most likely to preserve your fertility. You can also ask for a referral to a fertility specialist to help you understand and explore your options. Fertility specialists include:

Pregnancy and Breastfeeding

Pregnancy

Most people of childbearing age who have been treated for cancer and are able to conceive can go on to have low-risk pregnancies and healthy babies. Patients should be able to become pregnant if treatment did not affect their ovaries or uterus, and there are no other medical issues that may impact fertility. Before you try to become pregnant, talk with your treatment team about your medical readiness for pregnancy. You may also want to have a fertility assessment by consulting with a doctor called a “reproductive endocrinologist.”

Bereavement

Losing a child is possibly the most difficult thing a parent can experience. Grief can affect each person emotionally, physically, cognitively and behaviorally. Many people express grief in an outward way; for example, crying, a lack of energy or trouble sleeping. Others, on the surface, may not seem to be grieving. Instead, these people process grief internally. Their grief may go unrecognized and unacknowledged. Be aware that grief is personal and specific to the person. Try not to make judgments about how you, your co-parent or others process the loss of your child.

Side Effects

Most ALL treatment side effects are temporary and subside once the body adjusts to therapy or after the therapy is completed. If side effects become severe, children may need to be hospitalized.

Side effects common to ALL and its treatment include:

Nausea and Vomiting

Many cancer treatments can cause nausea and vomiting. Nausea, also called feeling “queasy” or “sick to your stomach,” is that unpleasant feeling you have when you are going to throw up. Vomiting is throwing up what is inside your stomach through the mouth. Nausea and vomiting can happen together, or one can occur without the other. The severity of nausea and vomiting varies among patients. Sometimes these side effects improve as you adjust to treatment, and most side effects go away after treatment ends.

Diarrhea and Constipation

Diarrhea and constipation are common side effects of cancer treatment. The severity of diarrhea or constipation varies among patients and depends on the type of treatment you receive. Sometimes side effects improve as you adjust to treatment. Most side effects go away when treatment ends.

Tell your healthcare team if you are experiencing new or worsening diarrhea or constipation. Do not take over-the-counter medications without talking to your doctor.

Diarrhea 

Follow these tips to manage diarrhea:

Disease Complications

In medicine, a complication is a medical problem that occurs during the course of a disease or after a procedure or treatment. Possible complications of ET include:

nina

Nina

Back in March 2015, my then 26-year-old daughter was not feeling well.  She had severe abdominal pain, overwhelming fatigue, night sweats, a low-grade fever, a headache, and appeared to be losing weight.  At the time, my daughter was working as a speech language pathologist in a hospital in Maryland.  She was misdiagnosed by an ER droctor and two months later, after her primary care doctor ordered an ultrasound, we found that she had innumerable tumors in her lungs and spleen.  We saw an oncologist the next day who ordered more blood work and a PET scan, as well as a bon

anaplastic large cell lymphoma (ALCL)

Naomi

My story begins when I was 11 years old, and I remember it being the summer after my sixth-grade year. I had just made the volleyball team and was so excited about that and the upcoming school year. I don't know if you remember middle school, but it was a bit of an awkward time, so I was looking forward to getting older, becoming surer of myself, and making more friends. Unfortunately, at some point during the summer, I started to feel fatigued.

a group of nine people standing at the top of a mountain holding a Climb2Cure banner

Alice

In March 2023, while visiting my daughter and son-in-law in San Francisco, I saw the Climb2Cure trip to Patagonia listed on The Leukemia & Lymphoma Society's (LLS) website. They have always talked about their backpacking trip to Patagonia in Argentina and Chile as their favorite hiking trip ever. This event would be my 16th LLS fundraising adventure since going into remission from multiple myeloma (MM) in 1999. 

Monica Sithole

Monica

I am currently 23 years of age and I’m from South Africa.  This is my story of my journey with Hodgkin lymphoma. This is a story of hope, a story of victory and a story meant to inspire those affected to keep holding on.  Towards late October of 2019, I noticed a bump protruding on my chest. It was a very hard and rigid bump which didn’t move. I was still in university completing my post-graduate diploma in accounting, so I didn’t think too much about it, my main stress was to complete my degree.

Big Climb

No matter where you live, no matter what your connection to cancer may be, you can step up to take cancer down by being a part of The Leukemia & Lymphoma Society’s Big Climb.

Take on a new challenge, by climbing to the top of iconic buildings, all while raising critical funds towards The Leukemia & Lymphoma Society’s mission to cure leukemia, lymphoma, Hodgkin's disease, and myeloma, and improve the quality of life of patients and their families.

Fertility and Pregnancy

Fertility, Pregnancy and TKIs 

Patients of childbearing age, as well as the parents of children with cancer, should ask their healthcare team to explain how treatment may affect fertility (the ability to have children). Patients with CML who will be taking TKIs should discuss fertility preservation with their doctors before starting TKI therapy.

Growing numbers of CML patients of childbearing age are living in stable remissions and are considering having children while being treated for CML. There is no risk that parents will pass the Ph chromosome onto their children.

Diagnosis

Diagnosing chronic myelomonocytic leukemia (CMML) usually involves a series of repeated tests, including blood and bone marrow tests. Your doctor usually can't confirm a diagnosis of CMML with one lab test result that shows abnormal blood counts. Instead, he or she will monitor you over a period of time with repeated lab tests that show abnormal blood counts. This is done to rule out other diagnoses.

Bone marrow testing involves two steps usually done at the same time in a doctor's office or a hospital:

Treatment

It's important that your doctor is experienced in treating patients with myeloma or works in consultation with a myeloma specialist. This type of specialist is usually called a hematologist oncologist.

Types of Treatment for Myeloma

Your treatment may include one or more of the following therapies:

The International Prognostic Scoring System

Specific factors may affect the prognosis (likely outcome) of MDS, and help doctors determine when to start treatment and how intensive the treatment should be. These factors include:

Your Treatment Team

Oncologists and hematologists are specialists who treat persons with leukemia, lymphoma, myeloma, myelodysplastic syndromes and myeloproliferative diseases. Pediatric hematologist oncologists treat children, adolescents and some young adults who have blood cancers. The oncologist or hematologist-oncologist coordinates a treatment and follow-up plan that involves other doctors as well as nurses, social workers, case managers and nutritionists.

 

Talking with Family, Friends and Children

Many people find it best to be honest with family and friends. By confiding in loved ones, you give them the chance to offer their support. It's true that some of your relatives or friends may not know what to say or do. But most do want to be supportive.

Consider "appointing" a willing family member or friend to be your "press secretary." He or she can be responsible for regularly letting others know your health status so you can focus on your treatment and recovery.

Possible Treatment Effects

Possible effects on sperm 

Sperm is made and stored in the testes. Sperm production begins at the onset of puberty and continues throughout the person’s life, although the amount and quality of sperm can naturally decrease with age. Cancer treatment can cause:

Fertility

People in the YA age group can be in many different stages of life. You may have children; you may want children in the future; you may not want children now, but may change your mind; or you may not have given it much thought at all. Cancer treatment can affect fertility in both women and men making it difficult to conceive a child in the future. A cancer diagnosis may require you to think seriously about children.

Not all cancer treatments affect fertility. Your risk depends on several factors, including