Dr. Sisi Chen is a Research Associate in the laboratory of Dr. Omar Abdel-Wahab at Memorial Sloan Kettering Cancer Center (MSK). Sisi obtained her Bachelor’s degree at Wuhan University, China and completed her PhD training at Indiana University under the mentorship of Dr. Yan Liu. During her graduate studies, Sisi studied the role of TP53 mutations in pre-malignant hematopoiesis. Due to her keen interests in blood cancer research, Sisi continued her scientific pursuits as a postdoctoral fellow in Dr. Daniel Tenen’s laboratory at Harvard Medical School and then joined the Abdel-Wahab laboratory at MSK in 2019. As an LLS Special Fellow, Sisi will focus on elucidating a novel mechanism by which dysregulated RAS signaling contributes to leukemia and drug resistance. Sisi plans to utilize mouse models and functional genomic approaches to define how impaired RAS degradation drives leukemia and identify novel therapeutic targets. Sisi hopes that her work will improve leukemia treatment, thereby benefiting leukemia patients in the future.