My research focuses on the translation of bench works into new therapeutic approaches/strategies for multiple myeloma and other blood cancers. One of my research goals is to study the mechanism underlying the pathogenesis of myeloma and its associated tumor microenvironment. I have been investigating the interaction of myeloma cells with bone marrow adipocytes, bone cells, and the signaling pathways associated with obesity, inflammation, chemo-, immune-therapeutic resistance, and bone disease, which are the major hurdles in treating myeloma. As a PI, I have managed many projects funded by extramural grants, private funds, and industry alliances. Some highlights include the NIH/NCI R01s and funding received from ASH and ACS. I have an excellent publication track record with peer-review articles that are in top-tier journals with high impact factors (e.g. Cell Metabolism, Science Translational Medicine, Cancer Cell). My research experience shows my capacity to be a PI for this Project.