I am Head of the Cancer and Stem Cell Laboratory, and my research has been focused on leukemia stem cell biology and targeted therapies in the past 15 years. I have an extensive background in leukemia research, with specific training and expertise in stem cell biology, patient-derived preclinical models, CRISPR-genome editing, and single-cell multi-omics. As PI on several NHMRC-funded grants, I laid the groundwork for the proposed research by uncovering new therapeutic targets and mechanisms, and by establishing partnerships with industry that will enable personalized therapies into clinical application. I successfully administered the projects (e.g. staffing, research protections, timeline, budget), collaborated with researchers, and produced publications from each project in leading scientific journals (e.g. Cancer Cell, Blood). The current application builds logically on my prior work. I have the expertise, leadership, and motivation necessary to successfully carry out this project.